منابع مشابه
Biologic markers in risk assessment for environmental carcinogens
The potential of biologic markers to provide more timely and precise risk assessments for environmental carcinogens is viewed against the current state-of-the-art in biological monitoring/molecular epidemiology. Biologic markers such as carcinogen-DNA adducts and oncogene activation are currently considered valid qualitative indicators of potential risk, but for most chemical exposures research...
متن کاملEPA priorities for biologic markers research in environmental health.
Recent advances in molecular and cellular biology allow for measurement of biologic events or substances that may provide markers of exposure, effect, or susceptibility in humans. The application of these new and emerging techniques to environmental health offers the possibility of significantly reducing the uncertainties that traditionally hamper risk assessments. The U.S. Environmental Protec...
متن کاملCarcinogenic risk assessment: are there dose thresholds for carcinogens?
While it has been generally accepted that genotoxic carcinogens have no dose threshold for their carcinogenic potential, there is increasing evidence that very low doses in fact are incapable of inducing tumours or preneoplastic lesions. Thus not only so-called epigenetic 'non-genotoxic' compounds like phenobarbital and benzene hexachloride, but also unequivocally genotoxic carcinogens like the...
متن کاملRisk Assessment for Environmental Health
This comprehensive and easy-to-read treatment of the various facets, history, and criticisms involved in risk assessment for environmental health focuses on tools and approaches used for humans in an environment involving potential chemical hazards. The first part introduces the underlying principles and techniques of the field, and the second examines case studies in terms of different risk as...
متن کاملBiologic screening of selected plant material for carcinogens.
The primary causes of most human cancers are still unknown. Most of the carcinogens studied in the laboratory have only a remote relationship to the human situation. For example, it is well-known that humans are not commonly exposed to compounds such as the azo dyes, the fluorenylacetamines, or urethan. Carcinogens such as j3-naphthylamine and benzidine, for which there is a known occupational ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1991
ISSN: 0091-6765
DOI: 10.2307/3430875